Congenital impairments affecting multiple body systems is under Listing 10.00 in Social Security's categories and the most prominent syndrome within it is likely Down syndrome. Down syndrome is often broken down into two separate, but related categories: Mosaic and non-mosaic.
There are of course many other disabilities that can be considered for Social Security Disability under the "Congenital Impairments Affecting Multiple Body Systems" category. Like other disabilities, it is very important to look at the Social Security's Listings (specifically 10.00) to fully understand what is looked at and required to qualify for disability. To learn more about Social Security Disability and how it may apply, I urge you to visit Social Security's website at www.ssa.gov.